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Pure Encapsulations PureGenomics B-Complex 120 caps

Original price $45.20 - Original price $45.20
Original price $45.20
$54.24 - $54.24
Current price $54.24

B-complex targeting common genetic polymorphisms*

PureGenomics® B-Complex is designed to address the nutrient requirements of common genetic variations in the methylation pathway with a unique blend of B vitamins in highly researched and activated forms. Folate is offered in this formula as Metafolin® 5-methyltetrahydrofolate (5-MTHF), the universally metabolized and biologically active form of folate, providing support for individuals with genetic variations in the MTHFR gene. Vitamin B12 is offered as a combination of hydroxycobalamin and adenosylcobalamin. Hydroxycobalamin is a precursor form of vitamin B12 converted in the body to both methylcobalamin and adenosylcobalamin. Adenosylcobalamin is an activated form stored in the mitochondria of cellular tissues. It is a key cofactor in carbohydrate metabolism and healthy synthesis of neuronal myelin. Benfotiamine is a lipid-soluble, enhanced-retention thiamin derivative.*

• Comprehensive B vitamin supplement
• Provides activated B vitamins, including pyridoxal-5-phosphate, riboflavin-5-phosphate, enhanced-retention thiamin derivative benfotiamine, and 800 mcg of Metafolin® L-5-methyltetrahydrofolate (L-5-MTHF), the naturally occurring, universally metabolized form of folate
• Offers vitamin B12 in unique blend of adenosylcobalamin and hydroxycobalamin
• Made with hypoallergenic, vegan ingredients
Serving Size:1 Vegetable Capsule
Servings Per Container:120

Amount Per Serving% Daily Value
Thiamin (as thiamin HCl) (B1)Amount Per Serving:25 mgDaily Value:2083%
Riboflavin (as vitamin B2 and 67% riboflavin 5' phosphate (activated B2))Amount Per Serving:15 mgDaily Value:1154%
Niacin (as niacinamide)Amount Per Serving:50 mgDaily Value:313%
Vitamin B6 (as pyridoxine HCl and 20% pyridoxal 5' phosphate (activated B6))Amount Per Serving:50 mgDaily Value:2941%
Folate (as Metafolin® L-5-MTHF 800 mcg) DFEAmount Per Serving:1333 mcgDaily Value:333%
Vitamin B12 (as adenosylcobalamin and 50% hydroxycobalamin)Amount Per Serving:800 mcgDaily Value:33333%
BiotinAmount Per Serving:400 mcgDaily Value:1333%
Pantothenic acid (as calcium pantothenate) (B5)Amount Per Serving:100 mgDaily Value:2000%
Choline (as choline bitartrate)Amount Per Serving:40 mgDaily Value:7%
InositolAmount Per Serving:25 mg
BenfoPure® benfotiamineAmount Per Serving:3 mg
Other Ingredients:
vegetarian capsule (cellulose, water), hypoallergenic plant fiber, ascorbyl palmitate


We work to ensure that product information is correct; however, brands may make changes to products from time to time, and actual product packaging and materials may contain more and/or different information than that shown on our website. Please consult all labels, warnings, and directions prior to using or consuming products for the most accurate product information.

  • Gluten Free
  • Non-GMO
Recommendations: As a dietary supplement, take 1 capsule daily, with a meal, or as directed by a health professional.
Gluten-free, Non-GMO & Hypoallergenic
Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.
Keep out of the reach of children. Use only if safety seal is intact. Store in a cool, dry place.

Customer Reviews

Based on 54 reviews
Im happy with

Im happy with them and plan to reorder.

I have spent

I have spent a lot of money trying to find supplements that work and don't hurt me. This product took away my leg cramps within 6 hours. I can now stretch my feet/calves however I like without severe cramps! I had 2 strokes and kidney failure (plus more unfortunately) last year and have felt substantial stomach pain every morning since, and struggle to get out of bed due to chronic fatigue. Doctors don't know what is going on or how to help. After a bunch of supplements that only hurt me more, this product has me waking up with very little stomach pain and some actual energy instead of dreading standing up and walking to the next room because of how it will effect me for the next hour and make my heart pound. 5 days after first starting and I feel like maybe I'm not drowning anymore. Sure hope Nestle doesn't change things.

P. Murphy
Works for me

Works for me

I discovered through

I discovered through genetic testing that I have genetic variations with MTHFR that up until 2019, were impacting my health. I began researching it and learned that methylated B vitamins, especially Methylated Folate, are very important. I began taking this supplement in February 2019 and I was pregnant by July. After a decade of miscarriages I had a healthy baby girl at age 44.5! MTHFR affects the bodys ability to process and absorb the folate in foods. The methylated form is absorbed into the body more easily.

I have used

I have used the PE regular B Complex and liked them. I saw these and thought I would try them and compare the difference. B Complex was suggested to me by a NP for Thyroid (Hashimoto's) support. I don't recall how quickly the regulars "worked"...but I feel with these, there were positive changes within about 72 hours. I highly recommend giving these a try.