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✦ AI Overview

MegaSporeBiotic™ (180 Capsules) by Microbiome Labs is a 100% spore-based, broad-spectrum probiotic clinically shown to maintain healthy gut barrier function, optimize immune health, and recondition the gut microbiome. Its unique blend of 5 dormant Bacillus spores delivers 4 Billion CFU with 99.99% digestive survivability — reaching the large intestine fully intact to colonize and increase microbial diversity. 180 capsules, 90-day supply at 2 capsules per day — best value size.

🧬 5-Strain Spore Formula 💪 4 Billion CFU 🧠 Gut Reconditioning ✅ No Refrigeration Required
🌍 Worldwide Delivery in 5–10 Days✅ Duties & Taxes PrepaidNo extra charges at delivery — what you pay at checkout is all you pay.
🏷️ Volume DiscountBuy 2 or more & save 5%Discount applied automatically at checkout.
✓ Dairy Free ✓ Gluten Free ✓ Soy Free ✓ Non-GMO ✓ Corn Free ✓ Preservative Free

Key Features

  • 100% Spore-Based, 5-Strain Formula — 295 mg / 4 Billion CFU Proprietary Spore Blend: B. licheniformis (SL-307), B. indicus HU36™, B. subtilis HU58™, B. clausii (SC-109), B. coagulans (SC-208).
  • 99.99% Digestive Survivability — Bi-phasic Bacillus life cycle allows spores to remain dormant through stomach acid and activate directly in the large intestine.
  • Reconditions the Gut — Actively promotes beneficial commensal bacteria colonization rather than simply passing through the digestive tract.
  • Immune & Barrier Support — Clinically shown to support healthy intestinal permeability (gut barrier function) and protective immune responses.
  • 180 Capsules — 90-Day Supply — 2 capsules per day; best value size; 100% shelf-stable, no refrigeration required.

Product Overview

MegaSporeBiotic™ is a 100% spore-based, broad-spectrum probiotic shown to maintain healthy gut barrier function. This unique all-spore formula effectively reconditions the gut by promoting microbial diversity and maintaining key health-promoting, commensal gut bacteria. Unlike conventional probiotics, MegaSporeBiotic’s Bacillus spores survive the entire digestive journey with 99.99% viability — no refrigeration required.

The 180-capsule size provides a full 90-day supply — the recommended minimum duration for meaningful gut microbiome reconditioning. Each serving delivers 4 Billion CFU across 5 clinically studied Bacillus strains, each with distinct mechanisms: carotenoid antioxidant production (HU36™), intestinal barrier support and antimicrobial peptides (HU58™), immune equilibrium (SC-109), digestive comfort (SC-208), and B vitamin and enzyme production (SL-307).

Technical Specifications

Brand / Vendor Microbiome Labs
Category Probiotics / Gut Health
Probiotic Strains B. licheniformis (SL-307), B. indicus HU36™, B. subtilis HU58™, B. clausii (SC-109), B. coagulans (SC-208)
Potency Per Serving 4 Billion CFU (295 mg Proprietary Spore Blend)
Capsule Count 180 Capsules
Serving Size 2 Capsules Daily
Supply Duration 90-Day Supply
Refrigeration Required No — shelf stable (5-year shelf life)
Certifications Gluten Free, Non-GMO, Dairy-Free, Soy-Free, Corn-Free

Supplement Facts

Serving Size: 2 CapsulesServings Per Container: 90
Amount Per Serving % Daily Value
Proprietary Spore Blend
4 Billion CFU 		295 mg   †
Bacillus licheniformis (SL-307) †
Bacillus indicus HU36™ †
Bacillus subtilis HU58™ †
Bacillus clausii (SC-109) †
Bacillus coagulans (SC-208) †

† Daily values not established.

Other Ingredients: Cellulose, vegetable capsule (cellulose and water).
Always verify full ingredient listings on physical product label upon receipt.

📊 Dosage & Usage Guide

Always follow label directions. Consult your healthcare practitioner before use if pregnant, nursing, or taking prescription medications.

Demographic Recommended Dose Frequency & Directions
Adults (18+) 2 Capsules Take 2 capsules once daily with or without food, or as directed by your healthcare professional.
Children (Under 18) Consult Practitioner Consult your healthcare practitioner before use.

💡 How to Use

Directions: Take 2 capsules once daily with or without food, or as directed by your healthcare professional.

Caution & Warnings: As with any dietary supplement, consult your healthcare practitioner prior to use if pregnant, nursing, or taking prescription medications. Keep out of reach of children.

Frequently Asked Questions

What makes MegaSporeBiotic different from regular probiotics?

MegaSporeBiotic is a 100% spore-based probiotic, meaning all 5 strains exist in a protective endospore state that survives stomach acid, heat, and manufacturing with 99.99% viability. Conventional Lactobacillus and Bifidobacterium probiotics typically lose 99%+ of their potency before reaching the intestines. MegaSporeBiotic’s spores arrive fully intact in the large intestine where they germinate, colonize, and actively recondition the microbiome — rather than simply passing through.

Why choose the 180-capsule size?

The 180-capsule bottle provides a full 90-day supply — the recommended minimum duration for meaningful gut microbiome reconditioning according to clinical research on spore-based probiotics. It is the best value per serving and eliminates the need to reorder monthly. Ideal for those committed to a long-term gut health protocol.

Does MegaSporeBiotic need to be refrigerated?

No. MegaSporeBiotic is 100% shelf-stable with a 5-year shelf life and requires no refrigeration. Store in a cool, dry place away from direct sunlight and heat.

Can MegaSporeBiotic be taken alongside other Microbiome Labs products?

Yes. MegaSporeBiotic is the cornerstone of the Microbiome Labs protocol and is commonly used alongside MegaPreBiotic, Mega IgG2000, HU58, and RestorFlora. It is also generally compatible with most vitamins, minerals, and other dietary supplements. Consult your healthcare provider if you are taking prescription medications.

How long does it take to see results with MegaSporeBiotic?

Individual results vary. Many users report noticeable improvements in digestive comfort and regularity within 2–4 weeks of consistent use. Clinical studies on spore-based probiotics have shown measurable changes in microbiome composition within 30 days. The 90-day supply is ideal for completing a full reconditioning cycle.

All content on the website relating to products including (or are a similar nature to) medicines, vitamins and supplements are not intended to be used for the diagnosis, treatment, cure, or prevention of any health condition or disease. The information provided on this page does not constitute advice and should not be taken over the advice of medical practitioners, pharmacists, or any other licensed healthcare professionals. You should contact your healthcare provider in relation to this product if you believe you have a medical issue. Please ensure that you always read the label and follow any instructions that come with the product before you use or consume. Please do not rely on the information stated on our website.