I was in debilitating pain from a long ago broken ankle, bunions, plantar fasciitis and a hematoma. And this weird pain thst would spiral through my arms and legs, typically settling into my knees and elbows. Geez. I was in constant pain and quite worried. I did NOT want to take a pharmaceutical. I did research for quite awhile and found serrapeptase. I can now hike, ski and play again! In fact, I enjoy it more and do it more than ever. I have told several friends about it and the ones that took my advice are quite amazed. (There have been a few that found it did not help them) This brand is good. I have to take 250,000 every morning. Then later if needed in a smaller dose. It was about week after starting that one morning I woke up with literally no pain. I walked around the house, amazed. Id been in pain for so long. I have been taking it for about a year now. Occasionally, I will skip a day or two here and there. I consider it a miracle.