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Pure Encapsulations Poly-Prebiotic powder 4.9 oz

Original price $40.30 - Original price $40.30
Original price $40.30
$48.36 - $48.36
Current price $48.36

Prebiotics are nondigestible components of food that act to modulate and support the gut microbiota. Emerging evidence suggests that they may play an even more significant role than probiotics, performing beneficial metabolic, trophic, and protective functions within the gut, leading to overall cellular, immune and metabolic support. Changes to the diet have been shown to alter microflora within just a few days. Restricted diets typically decrease microbiome diversity, while varied and diverse sources of fiber and polyphenols increase microbiome diversity. High-microbiome diversity has been linked to optimal health and resilience. PreticX™ XOS (xylooligosaccharide) and BioEcolians® α-GOS (alpha-glucooligosaccharide) both promote short-chain fatty acid (SCFA) production in the colon and Bifidobacteria in the GI tract. While XOS promotes the SCFA butyrate, a major energy source for the colonocytes, α-GOS promotes propionate to support both glucose homeostasis and satiety.

Bifidobacterium is the predominant intestinal bacterial genus during the first year of life and is associated with healthy immune development and cytokine balance, both in infants and later in life. In two comparison studies, obese children and children with celiac disease had lower levels of Bididobacteria compared to healthy controls. In a double-blind, randomized, placebo-controlled study, 32 healthy adult subjects were given 1.4 grams or 2.8 grams of PreticX™ XOS for eight weeks. The Bifidobacterium count increased 21% and 17% from baseline at four and eight weeks, respectively. In an in vitro study using clinical isolates from hospital patients, XOS was found to stimulate growth in all 35 Bifidobacterium strains tested. Other studies show XOS supports bowel motility, nutrient metabolism, and emotional wellness. In a randomized, double-blind, placebo-controlled trial involving 25 subjects, supplementation with 2 grams of α-GOS was found to support abdominal comfort by Day 7. Supplementation continued to offer increasing support throughout the 28-day period, including bowel motility and stool consistency.

A significant increase in B. longum, B. animalis and lactobacilli was also reported. In addition, BioEcolians® supplemented increased secretion in the mucosa of the antimicrobial peptides β-defensins. These molecules moderates adhesion of bacteria to the intestinal wall and supports healthy cytokine balance in the intestine. The health benefits of polyphenols may be due to their effects on the microflora. These compounds are generally not absorbed, but pass through the GI tract, where they are biotransformed to enhance bioavailability and support healthy gut microbial composition. In an animal study involving mice on a high-fat, high-sucrose diet, supplementation with cranberry polyphenols promoted healthy fat metabolism in the liver, insulin sensitivity, and cytokine balance. It was also shown to markedly increased Akkermansia muciniphila. Animal models indicate a role for Akkermansia on gut barrier function, including increased mucus layer thickness and production of occludin, an essential component of tight junctions.

Research suggests that polyphenols from blueberry and pomegranate support the growth of lactobacilli and bifidobacterium in the colon, as well as cytokine balance in the GI tract. In contrast to many common prebiotics, studies on XOS, α-GOS and polyphenols report very low incidence of gas, bloating or other intestinal side effects.*

• Blend of researched prebiotics and polyphenols with prebiotic effects*
• Targets Bifidobacteria and Akkermansia muciniphila to support GI barrier function*
• Pleasant-tasting fruit flavor
• Shelf-stable with low reported GI effects
• Made with hypoallergenic, vegan ingredients
Serving Size:1 Scoop
Servings Per Container:30

Amount Per Serving% Daily Value
CaloriesAmount Per Serving:10
Total CarbohydrateAmount Per Serving:3 gDaily Value:1%
Total SugarsAmount Per Serving:2 g
PreticX™ xylooligosaccharide (XOS)Amount Per Serving:1.4 g
BioEcolians® α-glucooligosaccharide (α-GOS)Amount Per Serving:1 g
Cranberry (Vaccinium macrocarpon) extract (fruit) (standardized to contain 12 mg proanthocyanidins (PACs))Amount Per Serving:1.2 g
Blueberry (Vaccinium angustifolium) extract (fruit) (standardized to contain 4% polyphenols)Amount Per Serving:100 mg
Pomegranate (Punica granatum) juice powder (fruit)Amount Per Serving:500 mg
Other Ingredients:
citric acid, malic acid, stevia leaf extract


We work to ensure that product information is correct; however, brands may make changes to products from time to time, and actual product packaging and materials may contain more and/or different information than that shown on our website. Please consult all labels, warnings, and directions prior to using or consuming products for the most accurate product information.

  • Gluten Free
  • Non-GMO

As a dietary supplement, take 1 serving, 1-2 times daily, mixed with a beverage or into food.

If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use. Keep out of the reach of children.

Use only if safety seal is intact. Packaged by weight, not volume. Settling may occur.

BioEcolians® is a registered trademark of Solabia.

Customer Reviews

Based on 26 reviews

I mean Sweet to taste, wish it was in capsule form.

Product is great, shipping arrived damaged.

I love the product and have ordered it several times. This time one of the bottles arrived shattered, not able to replace or return. Rather not risk swallowing glass shards. I do appreciate a glad bottle used by the seller and not plastic. Just needs to be packaged better for shipping by Amazon.

Product arrived quickly

I was advised by a medical professional to use Magnesium Glycinate to help prevent muscle cramps. Since I have used it, I rarely have cramps any more.

Roy P
Reduced my Liver enzymes

I've taken this preparation for some time. For me, it works. Not saying it'll work for everyone, but this preparation did reduce my liver enzymes to normal range on both standard liver test. I did note for me two capsules worked, one capsule a day did not bring enzymes to normal range. Not positive this preparation will work for severely damaged liver, but for mild fatty liver it proved effective in my case.

Mrs Collins (& occasionally Hubs)

I drop this tablet in my water and it fizzles. It has a tangy metallic taste that's not too intolerable but honestly I don't feel extra energetic or... anything. I haven't had any labwork done so I dont know if it has affected any body chemistry values per se. So I can't see any point in continuing to use them unfortunately. Was kind of just to see what would happen or if I would *feel* anything and I haven't. Made my mouth dry though that's about it.