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Pure Encapsulations Nrf2 Detox 60 caps

Original price $59.40 - Original price $59.40
Original price $59.40
$71.28 - $71.28
Current price $71.28

Targets Nrf2 to support detoxification and antioxidant defenses*

Cruciferous vegetables of the brassica family have long been recognized for their ability to support detoxification thereby maintaining healthy cells and tissues. Cruciferous vegetables, like broccoli, cauliflower, Brussels sprouts, and kale, are the richest sources of glucosinolates, which are considered to be the most bioactive constituents. Glucosinolates are converted in the body to isothiocyanates after they are ingested and hydrolyzed. The isothiocyanate sulforaphane is one of the most powerful activators of phase II enzyme function in the liver, supporting toxin elimination. Sulforaphane and resveratrol promote the activity of nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that supports the robust, long-lasting expression of numerous genes responsible for detoxification and protection against oxidative stress.

Among these genes are glutathione peroxidase, superoxide dismutase and various phase II enzymes, such as glutathione sulfotransferases. Nrf2 also supports expression of glutathione glutamylcysteinyl ligase, which is responsible for a critical step in the biosynthesis of glutathione, a vital component of cellular antioxidant and detoxification systems. Found in virtually every cell of the body, glutathione plays essential roles in protein synthesis, synthesis and repair of DNA, enzyme function, transport, and cell maturation. Optimal levels of glutathione have been associated with physical and mental health.

The highest concentration of glutathione is found in the liver, where it offers antioxidant support, protects tissue and maintains detoxification. In a randomized clinical trial, supplementation with 250 and 1,000 mg of Setria® glutathione per day increased glutathione levels in the blood after one, three and six months. At six months, mean glutathione levels in the high-dose group increased 30-35% in erythrocytes, plasma and lymphocytes, and 260% in buccal cells (P<0.05). In the low-dose group, mean glutathione levels increased by 17% and 29% in blood and erythrocytes, respectively (P<0.05). Both glutathione dose groups showed support for antioxidant defenses, indicated by decreases in the oxidized-to-reduced-glutathione ratio in whole blood after six months.*

• Supports detoxification and antioxidant defenses on a cellular level*
• Helps maintain healthy cells and tissues*
• Made with vegan ingredients

Serving Size:1 Vegetable Capsule
Servings Per Container:60

Amount Per Serving
Broccoli (Brassica oleracea italica) sprout concentrate (whole plant)(standardized to contain 1,000 mcg sulforaphane)Amount Per Serving:250 mg
Setria® glutathione (reduced form)Amount Per Serving:250 mg
resVida® resveratrol (as trans-resveratrol)Amount Per Serving:15 mg
Other Ingredients:
vegetarian capsule (cellulose, water)


We work to ensure that product information is correct; however, brands may make changes to products from time to time, and actual product packaging and materials may contain more and/or different information than that shown on our website. Please consult all labels, warnings, and directions prior to using or consuming products for the most accurate product information.

  • Gluten Free
  • Non-GMO
As a dietary supplement, take 1 capsule, 1-3 times daily, with meals.

If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.
Keep out of the reach of children.
Use only if safety seal is intact. Store in a cool, dry place.

Customer Reviews

Based on 5 reviews
Long Term Commitment

I do think this product works for detoxifying your body or assisting your body in at least clearing out free radicals. After a month, I felt a little more resilient when I overworked or didn't sleep as much as I should. I also received compliments on the way I look when nothing else has changed in my diet or routine. The drawback is: that was after a month of taking this product. It is quite expensive to continue long term at the current price it's at.

Dana Mahan
it's fine

I was looking for an alternate Nrf2 and chose this one because it was a little cheaper. I think its decent.


I have been taking this for 6 months and once it starts building up in the system, you will detox much more consistent. Glutathione helps to bind toxins and reduce the free radical hydrogen peroxide. The glutathione compound is patented, mainly because they have a study attached to it demonstrating that after several months of consumption, the glutathione in fact does she up in your cells. This is important, as many glutathione products are known to be poorly absorbed (hence many recommend the (1 out of 3) building blocks, which is NAC. In addition, PURE put in Reservatrol (anti-oxidant in grapes) and Sulphoraphanes (anti-oxidant in broccoli seeds) to stimulate the NRF2 cascade (unbinds the NRF2 intracellular protein from its inhibitor, which then travels to the nucleus and causes DNA upregulation of anti-oxidant genes such as catalase, GPX, SOD and GSTP). This product is a powerful adjunct, especially if you combine it with dietary changes (healthier choices, e.g. Paleo, low sugar, GF/DF) and other vitamin and nutrient support. 5 stars all the way. Haven't found a glutathione product with similar efficacy.

Theresa R.
Great for toddlers!

I ordered this for my newborn and toddler. I felt it made my newborn gassy even with only a quarter of the scoop. I would recommend this for an older infant 9 months +. I found a probiotic drop that agreed better with my newborn/1 month baby after trying this one. I really liked it for my toddler though. It dissolves really well and minimal effort into any cold liquid. I bought it originally because it had a good blend of the probiotics little ones need. It came with a scooper which is really convenient too. Dont forget to refrigerate!

Does the job.

With a toddler that has undergone multiple courses of antibiotics, we were eager to find a probiotic supplement that could help to rectify the damage that has been done to the digestive ecosystem. This supplement fits the bill, though there are two issues that need to be mentioned: (1) The product packaging is ridiculous. A big, big jar for a small, small actual amount of material. The dosage is also small, so it's not as though there's "not enough" or one feels as though one is being taken to the cleaners, it's just that the jar is so amazingly large that the tiny amount of material inside seems ridiculous by comparison and the amount of raw materials waste (plastics, etc.) is ridiculous. The thing ships 85% empty. Save the plastic. (2) It doesn't mix well. There may be now way around this given the nature of the material, but be prepared to work very hard to get this to dissolve in fluids, etc. Instead, it tends to clump in great dirty hunks that can't be broken up. On the positive side, since beginning supplementation with this product, the problem(s) at issue have largely disappeared, so it appears to be doing its work with aplomb.