I have very high Triglycerides thanks to very heavy drinking for decades (which I quit 2 weeks ago). I stated this supplement a week ago to help reduce my Triglycerides. I had taken Niacin at bedtime in the past and hated the hot flushing feeling it gave me in the middle of the night. I tried Non-flushing Niacin (inositol hexaniacinate) which I found out has no effect on Triglycerides. Niatab 500 is true Niacin and there is NO FLUSHING! I take it in the morning and never feel any side affects. I highly recommend Niatab 500 to anyone look for a true Niacin supplement!