I've had various health problems and concerns modern healthcare hasn't been so great at helping with. Thus I've studied on my own for probably thousands of hours and spent thousands of dollars trying to not feel like crap, every day. I've had gallbladder pains so it was removed. Still have some pain in that area. One Dr. noticed fatty liver on an ultrasound but said not to worry, it's not bad, it's common, etc. Another Dr. noticed higher than average liver enzymes, but also said, not to worry. I've always noticed over the years that generally anything that should help your liver, makes me feel better. Anything bad for your liver, well makes me feel like death. I've probably damaged my liver pretty well over the years. Too many antibiotics as a kid, accutane, mercury poisoning, fair amount of drinking, etc. I've always seen this supplement around but I don't see it mentioned a lot in literature. Most liver supplements make me feel worse, so I was cautious when I gave this a try. - ALA. First dose seems to make me feel good, then I feel progressively worse. I don't know if it's lowering my already low blood sugar, or what. - NAC. Similar to ALA. Feel slightly better at first, but then even more foggy and tired later in the day. - Choline supplements. BAAAD news. Make me very depressed, anxious, tired. This is known choline can make people depressed. - Milk Thistle. Either no effect or just makes me feel super lousy. Tired, spaced out, depressed, etc. - SAMe - Feel good first few days. Energetic and clear headed. Then comes this anxious, weird, just plain bad feeling. I've only taken this for about a week but I have noticed that I am sleeping better at night. This is HUGE because the last few years, my sleep is a serious problem. Also notice I wake up more clear headed. Also notice that my eyes are brighter, and actually green again. This is the first time in well over 10 years, I've seen that color green in my eyes. I forgot they used to look like that. People have commented my eyes and skin look brighter. I generally seem to react well to it. Some days/doses seem to make me feel the typical lethargic/spacey, but finally, the pros seem to outweigh the cons in a liver supplement. I will try to update this review in a month or so with liver ultrasounds and enzyme level tests to make sure there I'm really improving on paper as well.