My sister's integrative medicine doc recommended these to her for enflamed disc issues. I have spondylolisthesis and I notice a difference depending on inflammation in the body. It had gotten to the point where walking around the block was not fun at all let alone any distance. I started taking these and it has been a game changer. The key is empty stomach and consistency. I was not consistent as I couldn't seem to remember while having a completely empty stomach. So now I keep them by my bedside and I typically wake up for a drink of water or pee in the middle of the night, so I just take them then and the consistent taking them makes a massive difference!! I was able to go for a hike and going for a simple stroll now is something I don't have to think about, let alone lament! Worth every penny!! (I take 3 pills just once a day(night).