I started it about 8-9 months ago. Noticed my forehead wrinkles are much less pronounced. My nails are growing like gangbusters. I also take Turmeric Cucumin for anti-inflammatory purposes and feel like the two together have provided more relief so much so that I got off my prescription anti-inflammatory. Hair quit falling out at the rate that it was - my stylist has noticed. Since hair grows in right week cycles, I've got several months to go to see a true payoff but am hopeful. All in all this stuff does work and I've tried several others on Amazon as they sounded good in the description. But this one absorbs and several friends have more gotten on it too... But I do the pills cuz the powder just turned me off.